Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

Post-embryonic acute developmental processes mainly allow the transition from one life stage in a specific ecological niche to next different niche. Metamorphosis, an emblematic type of these post-embryonic processes, has occurred repeatedly and independently various phylogenetic groups throughout metazoan evolution, such as cnidarian, insects, molluscs, tunicates, or vertebrates. This review will focus on metamorphoses transitions vertebrates, including typical larval metamorphosis anuran amphibians, secondary teleost fishes, egg hatching sauropsids birth mammals. Two neuroendocrine axes, hypothalamic-pituitary-thyroid hypothalamic-pituitary-adrenal/interrenal are central players regulation transitions. The address molecular functional evolution axes their interactions. Mechanisms integration internal environmental cues, activation represent key questions “eco-evo-devo” perspective metamorphosis. roles played by innovation, adaptation, plasticity cycles vertebrates be discussed. In current context global climate change habitat destruction, also impact factors, warming endocrine disruptors